DL-Praeruptorin A
Praeruptorin A
CAS: 73069-25-7
Molecular Formula: C21H22O7
DL-Praeruptorin A - Names and Identifiers
| Name | Praeruptorin A |
| Synonyms | CCRIS 7247 Praeruptorin A PRAERUPTORIN A DL-Praeruptorin A (-)-Pareruptorin A (+)-praeruptorin A (+-)-Praeruptorin A Praeruptorin A Standard Praeruptorin ADL-Praeruptorin A 9,10-dihydro-8,8-dimethyl-2-oxo-2H, 8H- 2-Butenoicacid, 2-methyl-, (9S, 10S)-10-(acetyloxy)- (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2Z)-2-methylbut-2-enoate |
| CAS | 73069-25-7 |
| InChI | InChI=1/C21H22O7/c1-6-11(2)20(24)27-19-18(25-12(3)22)16-14(28-21(19,4)5)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-/t18-,19-/m1/s1 |
DL-Praeruptorin A - Physico-chemical Properties
| Molecular Formula | C21H22O7 |
| Molar Mass | 386.4 |
| Density | 1.28 |
| Melting Point | 135-139°C |
| Boling Point | 486.8±45.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)+3.3 |
| Flash Point | 211.534°C |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.574 |
| Physical and Chemical Properties | White Crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Peucedanum praeruptorum. |
DL-Praeruptorin A - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
DL-Praeruptorin A - Reference
| Reference Show more | 1. [IF=3.645] Xueqin Ding et al."Design of guanidinium ionic liquid based microwave-assisted extraction for the efficient extraction of Praeruptorin A from Radix peucedani."J Sep Sci. 2014 Dec;37(23):3539-3547 2. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
DL-Praeruptorin A - Reference Information
| Overview | praeruptorine A is a natural compound with calcium ion antagonism, it is widely found in a variety of plants such as Peucedanum praeruptorum Dunn, a plant of Umbelliferae. Peucedanum praeruptorum A is a kind of angle-type coumarin extracted from the root of Peucedanum praeruptorum. It is the main active ingredient of Peucedanum praeruptorum. |
| biological activity | (±)-Praeruptorin A is A diesterification product of cis-lactone (CKL), it is the main active ingredient in Peucedani Radix, consisting of the dried roots of Peucedanum praeruptorumdann. (±)-Praeruptorin A has been widely used as one of the traditional Chinese medicine, for the study with thick sputum and Dyspnea of Cough, non-native Cough and Upper Respiratory Infections. (±)-Praeruptorin A is mainly used as A Ca2-reflux blocker and can be used in the study of hypertension. |
| Target | Value |
| Use | praeruptorine A has antitussive, expectorant and antiasthmatic effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: Peucedanum a can inhibit Ca influx, promote K channel opening and other activities and anti-acute myocardial IRI effect. |
Last Update：2024-04-09 20:52:54
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